Hydrochloric Acid → Hydrochloric Acid
反応式
[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH:13]C(=O)OC(C)(C)C)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]>CO>[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH2:13])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]参加物
5
実験手順
A solution of tert-butyl [(3R)-1-phenylpiperidin-3-yl]carbamate (133 mg, 0.483 mmol) in 3 M HCl in MeOH (3 ml) was heated to 70° C. for 3 hr. The reaction mixture was concentrated in vacuo to provide crude (3R)-1-phenylpiperidin-3-amine as the bis HCl salt, which was used as-is without further purification.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-14f36128afe04dfba23dc66a4b1e28c8
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999957B2
反応ノート
読み込み中…