3,5-Difluoropyridine-4-carbaldehyde → (3,5-Difluoropyridin-4-yl)methanol
反応式
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9]>CO>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]参加物
3
実験手順
Title compound was prepared by a method analogous to that described for Intermediate 7, replacing 3,4-difluoro-2-pyridinecarbaldehyde with 3,5-difluoro-4-pyridinecarbaldehyde (FRONTIER) and using MeOH as solvent. (200 mg, 1.398 mmol, 73% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 8.51 (s, 2H), 5.55 (t, 1H), 4.55-4.57 (m, 2H). [ES+MS] m/z 146 (MH+).
出典と根拠
- ORDレコード
- ord-c121df29745840fb97cb226c93747f1f
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09000181B2
反応ノート
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