Triethylamine → (2-Chloropyridin-4-yl)methyl methanesulfonate

HRID 1467962

反応式

HRID 1467962 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[CH3:17][S:18]([O:9][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1)(=[O:20])=[O:19]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 7062237(2-Chloropyridin-4-yl)methanol

生成物 1

HCID 53436764(2-Chloropyridin-4-yl)methyl methanesulfonate収率 68.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of (2-chloropyridin-4-yl)methanol (0.500 g, 3.496 mmol) in dichloromethane (15 mL), triethylamine (0.424 g, 4.195 mmol) and methanesulfonylchloride (0.440 g, 3.846 mmol) were added at 0° C. and stirred at room temperature for 2-3 h. The reaction was quenched with water and extracted with dichloromethane. The organic layer was concentrated in vacuo to give (2-chloropyridin-4-yl)methyl methanesulfonate (0.530 g, 68%); MS: 221.9 (M+1).

後処理

  1. customThe reaction was quenched with water
  2. extractionextracted with dichloromethane
  3. concentrationThe organic layer was concentrated in vacuo

出典と根拠

ORDレコード
ord-dbe6dcafa19e4fc0b55dd62ddede6b56
出典データセット
uspto-grants-2015_04
特許番号
US09000175B2

関連ノート

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