Tert-butyl 4-hydroxypiperidine-1-carboxylate → tert-Butyl 4-((6-chloropyridin-3-yl)methoxy)piperidine-1-carboxylate

HRID 1467988ノート

反応式

HRID 1467988 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CS(O[CH2:20][C:21]1[CH:22]=[N:23][C:24]([Cl:27])=[CH:25][CH:26]=1)(=O)=O>>[Cl:27][C:24]1[N:23]=[CH:22][C:21]([CH2:20][O:14][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:9][CH2:10]2)=[CH:26][CH:25]=1

参加物

3

反応物 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 23020401(6-Chloropyridin-3-yl)methyl methanesulphonate

生成物 1

HCID 45786862tert-Butyl 4-((6-chloropyridin-3-yl)methoxy)piperidine-1-carboxylate

実験手順

The title compound was prepared by following the similar procedure as described in Intermediate-42 using 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester and (6-chloropyridin-3-yl)methyl methanesulfonate; MS: 227 (M−100).

出典と根拠

ORDレコード
ord-3563e2de9ec64eb0a24ff58d73401c08
出典データセット
uspto-grants-2015_04
特許番号
US09000175B2

反応ノート

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