Cyclobutylcarbinol → HCID 67979411、化合物
反応式
F[C:2]1(F)[CH2:5][CH:4]([CH2:6][O:7][C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][CH2:13][C:14]3=[O:17])=[CH:10][CH:9]=2)[CH2:3]1.[OH:19][C:20]1[CH:28]=[C:27]2C(CCC2=O)=[CH:22][CH:21]=1.C1(CO)CCC1>>[CH:4]1([CH2:6][O:7][C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][C:13]4([CH2:27][CH2:28][C:20](=[O:19])[CH2:21][CH2:22]4)[C:14]3=[O:17])=[CH:10][CH:9]=2)[CH2:5][CH2:2][CH2:3]1参加物
4
反応条件
- 温度
- 45 °C
実験手順
The title compound (2.56 g, 58% yield) was prepared using the procedure described for Intermediate 11, starting from 6-hydroxy-2,3-dihydro-1H-inden-1-one (3.0 g, 20.3 mmol) and cyclobutylmethanol (2.10 mL, 22.3 mmol). The mixture was heated to 45° C. and left stirring over a weekend. 1H NMR (500 MHz, CDCl3) δ ppm 1.81-2.03 (m, 4H), 2.11-2.20 (m, 2H), 2.69-2.74 (m, 2H), 2.78 (dt, 1H), 3.04-3.12 (m, 2H), 3.96 (d, 2H), 7.17-7.22 (m, 2H), 7.36 (d, 1H); MS (ES+) m/z 217 [M+H]+.