3-Chloro-5-cyanophenylboronic acid, pinacol ester → US9000184, 10, isomer 1

HRID 1468242ノート

反応式

HRID 1468242 の反応式
Br[C:2]1[CH:24]=[C:23]2[C:5]([CH2:6][CH2:7][C:8]3([C:16]42[N:20]=[C:19]([NH2:21])[C:18]([CH3:22])=[N:17]4)[CH2:13][CH2:12][CH:11]([O:14][CH3:15])[CH2:10][CH2:9]3)=[CH:4][CH:3]=1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:31]=[C:32](B2OC(C)(C)C(C)(C)O2)[CH:33]=1)[C:29]#[N:30]>>[NH2:21][C:19]1[C:18]([CH3:22])=[N:17][C:16]2([C:23]3[C:5](=[CH:4][CH:3]=[C:2]([C:32]4[CH:31]=[C:28]([CH:27]=[C:26]([Cl:25])[CH:33]=4)[C:29]#[N:30])[CH:24]=3)[CH2:6][CH2:7][C:8]32[CH2:13][CH2:12][CH:11]([O:14][CH3:15])[CH2:10][CH2:9]3)[N:20]=1

参加物

3

反応物 2

HCID 532171293-Chloro-5-cyanophenylboronic acid, pinacol ester2 回HCID 72714746US9000184, 5, isomer 1

生成物 1

HCID 72714844US9000184, 10, isomer 1

実験手順

The title compound was prepared following the procedure described for Example 2, starting from 7′-bromo-4-methoxy-5″-methyl-3′,4′-dihydrodispiro[cyclohexane-1,2′-naphthalene-1′,2″-imidazol]-4″-amine (Example 5, 125 mg, 0.32 mmol) and 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (Intermediate 4, 93 mg, 0.35 mmol). The product was purified using preparative chromatography followed by concentration of the fractions, extraction of the remaining aqueous phase with DCM, washing the organic layer with water and concentration and drying in vacuo at 50° C. for 2 days to give:

後処理

  1. customThe product was purified
  2. extractionfollowed by concentration of the fractions, extraction of the remaining aqueous phase with DCM
  3. washwashing the organic layer
  4. concentrationwith water and concentration
  5. customdrying in vacuo at 50° C. for 2 days
  6. customto give

出典と根拠

ORDレコード
ord-c35a426b2f1d4d68828dbaaa5106e234
出典データセット
uspto-grants-2015_04
特許番号
US09000184B2

反応ノート

読み込み中…