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HRID 14683作成日：2026年10月25日

3-(Methylaminomethyl)pyridine → {6,7-Dimethoxy-4-[(methyl-pyridin-3-ylmethyl-carbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/14683

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Methylaminomethyl)pyridineHCID 88393—
反応物[1-(Tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acidHCID 68613423—
生成物{6,7-Dimethoxy-4-[(methyl-pyridin-3-ylmethyl-carbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl esterHCID 68613824—

反応手順

As described in Example 1, 94 mg of [1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acid was coupled with methyl-pyridin-3-ylmethyl-amine to give {6,7-dimethoxy-4-[(methyl-pyridin-3-ylmethyl-carbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester. MS: APCI (M+H) calc'd for C26H32N4O5+H 481.6; found 481.0.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07732446B1
出典データセットuspto-grants-2010_06
ORD IDord-a0ac811f42c444e8a977a6b2590f6f35
出典メモuspto-grants-2010_06