Butaclamol → Dopamine

HRID 1468603

反応式

HRID 1468603 の反応式
C[N:2]1[CH2:12][C@H:11](C2C=CC=CC=2)[C:10]2[CH:9]=[C:8]([OH:19])[C:7](Cl)=[CH:6][C:5]=2CC1.CC([C@]1([OH:47])C[C@H]2N(C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:2][CH2:12][CH2:11][C:10]1[CH:5]=[CH:6][C:7]([OH:47])=[C:8]([OH:19])[CH:9]=1

参加物

3

反応物 2

HCID 37461ButaclamolHCID 3036864R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol

生成物 1

HCID 681Dopamine

実験手順

HEK cells were transfected with DNA encoding D1-NLS-GFP (2 micrograms), and D1-WT (6 micrograms) for 48 hours. These cells were treated 6 hrs after transfection with SCH-23390 (10 micromolar), or (+)butaclamol (10 micromolar). The medium containing antagonist was changed at 6, 22, 30 and 42 hours after transfection. Control cells received no antagonist treatment.

後処理

  1. additionThe medium containing antagonist
  2. customwas changed at 6, 22, 30 and 42 hours

出典と根拠

ORDレコード
ord-2d53400f0aa94749a7bcb6d4c13f86c7
出典データセット
uspto-grants-2015_04
特許番号
US09005905B2

関連ノート

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