Hydrochloric Acid → Azepan-4-ol--hydrogen chloride (1/1)
反応式
[OH:1][CH:2]1[CH2:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:16]>C(OCC)(=O)C>[ClH:16].[NH:5]1[CH2:6][CH2:7][CH2:8][CH:2]([OH:1])[CH2:3][CH2:4]1参加物
4
実験手順
To a solution of tert-butyl 4-hydroxyazepane-1-carboxylate (1.00 g, 4.65 mmol) in ethyl acetate (23 ml) was added 4N hydrogen chloride in ethyl acetate (23 ml, 92.0 mmol). The mixture was stirred at room temperature for 5 hours. The mixture was concentrated in vacuo to afford azepan-4-ol hydrochloride as a pale yellow oil (710 mg, 4.65 mmol, >99%). This compound was used for the next reaction without further purification.
後処理
- concentrationThe mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-4bfe68cb7f624b478e9a672f5be5e9d9
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006232B2
反応ノート
読み込み中…