5,8-Dibromoimidazo[1,2-a]pyrazine → N-(5-bromoimidazo[1,2-a]pyrazin-8-yl)-5-((tert-butyldimethylsilyloxy)methyl)thiazol-2-amine
反応式
[Br:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5](Br)=[N:4][CH:3]=1.[Si:12]([O:19][CH2:20][C:21]1[S:25][C:24]([NH2:26])=[N:23][CH:22]=1)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[Br:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([NH:26][C:24]2[S:25][C:21]([CH2:20][O:19][Si:12]([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:14])=[CH:22][N:23]=2)=[N:4][CH:3]=1参加物
3
実験手順
Prepared from Intermediate 2 and Intermediate 7 using the procedure described in Example 1, Step 1. MS (MH+, m/z) 440.
出典と根拠
- ORDレコード
- ord-e776fa2d772041bead1be1f1419ddcfe
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006237B2
反応ノート
読み込み中…