Cesium carbonate → 5-ethoxy-2-(4-((1R,2R)-2-(((3-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidine

反応式

Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][C:20]=1[S:21]([CH3:24])(=[O:23])=[O:22])[CH2:6][O:7][CH2:8][C@@H:9]1[CH2:11][C@@H:10]1[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C([O-])([O-])=O.[Cs+].[Cs+].Cl[C:32]1[N:37]=[CH:36][C:35]([O:38][CH2:39][CH3:40])=[CH:34][N:33]=1>CS(C)=O.CCOC(C)=O>[CH2:39]([O:38][C:35]1[CH:34]=[N:33][C:32]([N:15]2[CH2:14][CH2:13][CH:12]([C@H:10]3[CH2:11][C@H:9]3[CH2:8][O:7][CH2:6][C:5]3[CH:18]=[CH:19][C:20]([S:21]([CH3:24])(=[O:22])=[O:23])=[C:3]([F:2])[CH:4]=3)[CH2:17][CH2:16]2)=[N:37][CH:36]=1)[CH3:40]