Potassium Hydroxide → 3-Bromo-4-methoxyphenol

A solution of potassium hydroxide (290 mg, 5.19 mmol) in water (2.5 mL) was added to a solution of acetic acid 3-bromo-4-methoxy-phenyl ester (1.2 g, 4.9 mmol) in methanol (18.5 mL). Mixture was stirred at ambient temperature for 30 min, then solvents were removed in vacuo and water (40 mL) added. The mixture was made acidic by drop-wise addition of 1.2 M aq HCl solution (4.3 mL) and the mixture extracted with dichloromethane (2×40 mL). Combined organics were dried over sodium sulphate, filtered and filtrate solvents evaporated in vacuo to give the title compound (976 mg, 98%) as a pale yellow solid.

1. customsolvents were removed in vacuo and water (40 mL)
2. additionadded
3. additionThe mixture was made acidic by drop-wise addition of 1.2 M aq HCl solution (4.3 mL)
4. extractionthe mixture extracted with dichloromethane (2×40 mL)
5. dry with materialCombined organics were dried over sodium sulphate
6. filtrationfiltered
7. customfiltrate solvents evaporated in vacuo

ORDレコード

ord-69d910966cbf4a12bdc5f3d754518554

出典データセット

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09006269B2