関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl Acrylate | HCID 7294 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-Iodo-2-methyl-1,3-benzothiazole | HCID 807592 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester | HCID 67505787 | — |
反応手順
A mixture of 6-iodo-2-methylbenzo[d]thiazole (275 mg, 1 mmol), methyl acrylate (103 mg, 1.2 mmol), diacetoxypalladium (22 mg, 0.1 mmol) and triethylamine (304 mg, 3 mmol) MeCN (8 mL) is heated in a microwave apparatus at 100° C. for 10 min. The solvent is removed under reduce pressure and the residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester. MS 234.3 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09006249B2 |
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| 出典データセット | uspto-grants-2015_04 |
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| ORD ID | ord-c7874f8223fe480ba751f892847c0abd |
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| 出典メモ | uspto-grants-2015_04 |
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