関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl 3-butenoate | HCID 77314 | — |
| 反応物 | 6-Iodo-2-methyl-1,3-benzothiazole | HCID 807592 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester | HCID 67505910 | — |
反応手順
A mixture of 6-iodo-2-methylbenzo[d]thiazole (275 mg, 1 mmol), but-3-enoic acid methyl ester (100 mg, 1.2 mmol), diacetoxypalladium (22 mg, 0.1 mmol) and triethylamine (304 mg, 3 mmol) MeCN (8 mL) is heated in a microwave apparatus at 130° C. for 30 minutes. The solvent is removed under reduce pressure and the residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester. MS 248.3 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09006249B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-53a6c4fa039b49bf999bd75a0eb18c20 |
|---|
| 出典メモ | uspto-grants-2015_04 |
|---|
