Hydrochloric Acid → HCID 67505771、化合物

HRID 1469678ノート

反応式

HRID 1469678 の反応式
[CH2:1]([O:3][C:4](=[O:31])[C@@H:5]([CH3:30])[CH2:6][CH:7]([NH:22]C(OC(C)(C)C)=O)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:2].Cl>C(Cl)Cl>[ClH:21].[CH2:1]([O:3][C:4](=[O:31])[C@@H:5]([CH3:30])[CH2:6][CH:7]([NH2:22])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67505776(S)-4-tert-butoxycarbonylamino-5-(3'-chloro-biphenyl-4-yl)-2-methyl-pentanoic acid ethyl ester

生成物 1

HCID 67505771HCID 67505771、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Next, to a solution of (S)-4-tert-butoxycarbonylamino-5-(3′-chloro-biphenyl-4-yl)-2-methyl-pentanoic acid ethyl ester (2.47 g, 5.54 mmol) in DCM (15 mL) is added 5 mL of HCl (4N in dioxane) and the mixture is stirred at room temperature for 2 hours. The solvent is removed under reduced pressure to afford the title compound; HPLC Retention time 1.48 minutes (condition C): MS 346.2 (M+1).

後処理

  1. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-09c279bfdc8f4f22ad82586a86df37aa
出典データセット
uspto-grants-2015_04
特許番号
US09006249B2

反応ノート

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