関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| 反応物 | 2-Amino-5-methylthiazole | HCID 351770 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 5-Methyl-3-(tetrahydro-pyran-2-ylmethyl)-3H-thiazol-2-ylideneamine | HCID 66859610 | — |
反応手順
A mixture of 2-amino-5-methylthiazole (1.2 g, 11 mmol) and 2-(bromomethyl)tetrahydro-2H-pyran (1.5 mL, 12 mmol) was warmed to 85° C. and stirred for 18 hours. The mixture was cooled to ambient temperature and purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 213 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09006275B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-ac4974e7146346dda5c8dbd0ddc1de22 |
|---|
| 出典メモ | uspto-grants-2015_04 |
|---|
