Benzenemethanamine, 2,4-dichloro-N-methyl- → 1-(3-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

HRID 1470068ノート

反応式

HRID 1470068 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[CH:6]=1)=[O:4].[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[CH2:20][NH:21][CH3:22]>O1CCOCC1>[Br:11][C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][N:21]([CH2:20][C:14]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=2[Cl:12])[CH3:22])[CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-HCID 5195852-Bromo-1-(3-bromophenyl)ethan-1-one

生成物 1

HCID 674555871-(3-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
25 °C

実験手順

Into a 1 L 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-bromo-1-(3-bromophenyl)ethanone (55 g, 199.28 mmol, 1.00 equiv) in 1,4-dioxane (300 mL), TEA (40 g, 396.04 mmol, 1.99 equiv), and (2,4-dichlorophenyl)-N-methylmethanamine (38 g, 201.06 mmol, 1.01 equiv). The resulting solution was stirred for 2 h at 25° C. in an oil bath. The solids were filtered out and the filtrate was used without any further purification.

後処理

  1. customInto a 1 L 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. filtrationThe solids were filtered out
  4. customthe filtrate was used without any further purification

出典と根拠

ORDレコード
ord-6db30afd96854dd58d46af7ab662122d
出典データセット
uspto-grants-2015_04
特許番号
US09006281B2

反応ノート

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