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2,4-Dichloropyrimidine → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 反応物 | 3-Formylphenylboronic acid | HCID 2734356 | — |
| 生成物 | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | 60% |
反応手順
2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 610.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-e0e0050b65ba4b42a63f0cab5037d450 |
| 出典メモ | uspto-grants-2010_06 |