Potassium Hydroxide → HCID 178426257、化合物

HRID 1470224ノート

反応式

HRID 1470224 の反応式
[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[N-:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1.[K+].[OH-].[K+]>O.Cl>[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[NH:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 443866Pemirolast potassium

生成物 1

HCID 178426257HCID 178426257、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

Pemirolast free acid was prepared by dissolving pemirolast potassium in water and acidifying to pH 1 with 6M HCl which caused the free acid to precipitate from solution. The crystals formed were filtered, washed with water and dried under vacuum. Pemirolast potassium was in turn prepared analogously to the methodology described in Example 4 (steps Ia and Ib) below, using 2M KOH instead of 2M NaOH, and recrystallising from water:isopropanol in a 1:2, instead of a 2:1, ratio.

後処理

  1. customto precipitate from solution
  2. customThe crystals formed
  3. filtrationwere filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customprepared analogously to the methodology
  7. customrecrystallising from water

出典と根拠

ORDレコード
ord-be2ce49101144f7ea7005d3cfff820d5
出典データセット
uspto-grants-2015_04
特許番号
US09006431B2

反応ノート

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