Sodium Methoxide → HCID 24766191、化合物
反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH3:12])[C:5](Cl)=[N:4][CH:3]=1.[CH3:14][O-:15].[Na+]>CO>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH3:12])[C:5]([O:15][CH3:14])=[N:4][CH:3]=1参加物
4
実験手順
To a stirred solution of 4-bromo-1-chloro-5-methylisoquinoline (Intermediate-5) (5.0 g, 19.5 mmol) in dry MeOH (100 mL) was added NaOMe (1.3 g, 23.4 mmol) and the reaction mixture was refluxed overnight. Solvent was removed and the resultant crude product was extracted with EtOAc (2×200 mL), washed with water (2×100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to furnished the title compound (4.5 g, 93%).
後処理
- temperaturethe reaction mixture was refluxed overnight
- customSolvent was removed
- extractionthe resultant crude product was extracted with EtOAc (2×200 mL)
- washwashed with water (2×100 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6b82e8f8e4824b67a91895990ffbd6a8
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006442B2
反応ノート
読み込み中…