2-Oxa-7-azaspiro[3.5]nonane → (1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-7-azaspiro[3.5]nonan-7-yl)methanone

反応式

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH2:16]1[C:19]2([CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH2:18][O:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:22]2[CH2:23][CH2:24][C:19]3([CH2:16][O:17][CH2:18]3)[CH2:20][CH2:21]2)=[O:15])=[CH:4][N:3]=1

参加物

反応物 2

HCID 219552842-Oxa-7-azaspiro[3.5]nonane

HCID 84687221HCID 84687221、化合物

生成物 1

HCID 86689591(1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-7-azaspiro[3.5]nonan-7-yl)methanone

実験手順

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2-oxa-7-azaspiro[3.5]nonane by following the similar procedure as described for intermediate-11a.

出典と根拠

ORDレコード: ord-a16c381c4d6f44b8aa6fc36ada03b9ef
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09006442B2

反応ノート

読み込み中…