(S)-4-(4-Aminobenzyl)oxazolidin-2-one → (S)-4-(4-hydrazinobenzyl)-2-oxazolidinone
反応式
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C@H:7]2[CH2:11][O:10][C:9](=[O:12])[NH:8]2)=[CH:4][CH:3]=1.[N:15]([O-])=O.[Na+]>Cl>[NH:1]([C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C@H:7]2[CH2:11][O:10][C:9](=[O:12])[NH:8]2)=[CH:4][CH:3]=1)[NH2:15]参加物
4
実験手順
In an embodiment, (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one of formula (II), which was prepared using prior art methods was treated with an aqueous solution of sodium nitrite in concentrated hydrochloric acid at −5 to 10° C. After completion of reaction based on HPLC, the resulting diazonium salt was treated with stannous chloride in hydrochloric acid at −15 to 10° C. to give (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one of formula (III).
後処理
- customAfter completion of reaction
出典と根拠
- ORDレコード
- ord-e5eb426f533c4940bdeb3cb6d626c521
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006453B2
反応ノート
読み込み中…