Diazomethane → Methyl 4-bromo-2,3,5,6-tetrafluorobenzoate
反応式
[Br:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:13])[C:3]=1[F:14].[N+](=[CH2:17])=[N-]>CO>[CH3:17][O:7][C:6](=[O:8])[C:5]1[C:4]([F:13])=[C:3]([F:14])[C:2]([Br:1])=[C:10]([F:11])[C:9]=1[F:12]参加物
4
実験手順
To a solution of 4-bromo-2,3,5,6-tetrafluoro-benzoic acid (20 g, 73.49 mmol) in methanol (20 mL) was added an ethereal solution of diazomethane gas until the starting material is completely consumed. Reaction mixture was then evaporated under reduced pressure. The crude solid obtained was purified by flash column chromatography using 5% ethyl acetate in hexane, to obtain title compound as colorless crystalline solid (18 g, 85%).
後処理
- customis completely consumed
- customReaction mixture
- customwas then evaporated under reduced pressure
- customThe crude solid obtained
- customwas purified by flash column chromatography
出典と根拠
- ORDレコード
- ord-d77135383d1b4b8db240f572ea533946
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
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