Diazomethane → Methyl 2-amino-5-chloro-3-nitrobenzoate

HRID 1470622ノート

反応式

HRID 1470622 の反応式
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+](=[CH2:17])=[N-]>CO>[CH3:17][O:5][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([Cl:14])[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[NH2:1]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 2320552-Amino-5-chloro-3-nitrobenzoic acid

生成物 1

HCID 615489Methyl 2-amino-5-chloro-3-nitrobenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-amino-5-chloro-3-nitro-benzoic acid (2 g, 1.0 mmol) in methanol (100 mL) was added a saturated ethereal solution of diazomethane gas (50 mL) till all the starting material was consumed. The reaction mixture was concentrated to dryness and the residue obtained was purified by column chromatography using 5% ethyl acetate in hexane as an eluent to obtain the title compound as yellow solid which was directly used for the next step (1.8 g, 84.11%).

後処理

  1. customwas consumed
  2. concentrationThe reaction mixture was concentrated to dryness
  3. customthe residue obtained
  4. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-d06d9bf51a264e35af1a34157235202a
出典データセット
uspto-grants-2015_04
特許番号
US09006454B2

反応ノート

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