Acetone → 2-Methoxy-4-phenylbenzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[CH:9]=[O:10].CC(C)=[O:19]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[C:9]([OH:19])=[O:10]参加物
3
実験手順
To a cold solution of 3-methoxy-biphenyl-4-carboxaldehyde (0.32 g, 1.5 mmol) in acetone (10 mL), the Jone's reagent was added slowly drop wise at 0° C. until the reaction completes. Acetone was removed completely and the resulting residue was diluted with water, extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulphate and concentrated to obtain the title compound (0.25 g, 73.5%)
後処理
- customAcetone was removed completely
- additionthe resulting residue was diluted with water
- extractionextracted with ethyl acetate
- washThe combined organic layers were washed with water and brine
- dry with materialdried over sodium sulphate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f375edc84d7847e68ba03792a09ca254
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
読み込み中…