Sulfuric Acid → 7-Iodoisatin

HRID 1470637ノート

反応式

HRID 1470637 の反応式
ON=[CH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[I:13])=[O:5].[OH:14]S(O)(=O)=O>>[I:13][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[C:3]2=[O:14]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 63998232-(Hydroxyimino)-N-(2-iodophenyl)acetamide

生成物 1

HCID 40437057-Iodoisatin収率 87%

反応条件

温度
85 °C

実験手順

2-(hydroxyimino)-N-(2-iodophenyl)acetamide (3.2 g, 0.011 mmol) was added to conc. H2SO4 (15 mL) in small portions at 60° C. The reaction mixture was further heated at 85° C. for 5 h. After the reaction completion, the reaction mixture was cooled to room temperature and poured into crushed ice. A brown color solid product precipitated. It was then filtered and washed with chilled water several times, then dried in a vacuum oven to get 2.9 g of the required product as a red coloured solid (87%).

後処理

  1. temperatureAfter the reaction completion, the reaction mixture was cooled to room temperature
  2. additionpoured
  3. custominto crushed ice
  4. customA brown color solid product precipitated
  5. filtrationIt was then filtered
  6. washwashed with chilled water several times
  7. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-1b14c10ffc9f42068fb6b542d51a8c66
出典データセット
uspto-grants-2015_04
特許番号
US09006454B2

反応ノート

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