C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)[C:5]=1[NH2:24].CC(C)([O-])C.[K+].O>CN1C(=O)CCC1>[C:15]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:17][C:12]([C:11]2[NH:24][C:5]3[C:6]([CH:10]=2)=[CH:7][CH:8]=[CH:9][C:4]=3[C:3]([OH:2])=[O:25])=[CH:13][CH:14]=1To a cold solution of 2-amino-3-biphenyl-4-ylethynyl-benzoic acid methyl ester (300 mg, 0.91 mmol) in NMP (5 mL) was added dropwise a solution of potassium t-butoxide (205 mg, 1.83 mmol) in NMP (5 mL). This reaction mixture was allowed to stir at room temperature for 5 h. After the reaction is completed it was poured into water and pH was adjusted to 2. The resulting precipitate was collected by filtration and was washed with water. Finally it was dried in a vacuum oven to get the 145 mg of 2-biphenyl-4-yl-1H-indole-7-carboxylic acid as a pale yellow coloured solid.
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