Acetone → 4-(4-cyanophenoxy)benzoic acid
反応式
[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2].CC(C)=[O:20]>>[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]([OH:20])=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2]参加物
3
実験手順
To an ice cold solution of 4-(4-cyano-phenoxy)-benzaldehyde (2.0 g, 8.9 mmol) in acetone (10 mL), the Jone's reagent (7 mL) was added slowly drop wise until reaction completes. Acetone was removed completely and diluted with water. The mixture was extracted with ethyl acetate. the combined organic layers were dried over anhydrous sodium sulphate and concentrated to get the title compound (1.5 g, 70%)
後処理
- customwise until reaction
- customAcetone was removed completely
- additiondiluted with water
- extractionThe mixture was extracted with ethyl acetate
- dry with materialthe combined organic layers were dried over anhydrous sodium sulphate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0591465904c14d5196c6ca15e0368da8
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
読み込み中…