Benzoic Acid → 5-Chloro-2-phenyloxazolo[5,4-d]pyrimidine
反応式
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:16]=[CH:15][C:14]([NH2:17])=[C:13](Cl)[N:12]=1>O=P(Cl)(Cl)Cl>[Cl:10][C:11]1[N:12]=[CH:13][C:14]2[N:17]=[C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[O:9][C:15]=2[N:16]=1参加物
4
実験手順
7.82 g (64.0 mmol) Benzoic acid and 20 mL POCl3 are stirred together at 100° C. for 30 min. Within 45 min 7.00 g (42.7 mmol) 2,6-dichloro-5-aminopyrimidine are added in several portions. The reaction mixture is stirred for additional 2 h at the same temperature. After that time, the mixture is carefully added to an ice cold aq. NaOH solution. The resulting precipitate is filtered off, washed with water and dried.
後処理
- filtrationThe resulting precipitate is filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-47cdd05759e44723b52903f0d903be09
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006450B2
反応ノート
読み込み中…