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4-Hydroxybenzylamine → N-(3-Amino-propyl)-N-{3-[2-(4-hydroxy-benzylamino)-pyrimidin-4-yl]-benzyl}-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybenzylamine | HCID 97472 | — |
| 反応物 | (3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-propyl)-carbamic acid tert-butyl ester | HCID 86603242 | — |
| 生成物 | N-(3-Amino-propyl)-N-{3-[2-(4-hydroxy-benzylamino)-pyrimidin-4-yl]-benzyl}-methanesulfonamide | HCID 58603579 | — |
反応手順
Intermediate 4 from above was coupled with 4-aminomethyl-phenol following procedure F and the resulting product deprotected following procedure G. LC-MS showed the product had the expected M+H+ of 442.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-8bb62e73a0bc4ceb817b3ba09e0e0e43 |
| 出典メモ | uspto-grants-2010_06 |