関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | 1,4-Bis(4-nitrophenyl)butane-1,4-dione | HCID 13762891 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(4-Fluorophenyl)-2,5-bis(4-nitrophenyl)-1H-pyrrole | HCID 58226815 | 91% |
反応手順
To a slurry of the product from Example 1A (1.5 g, 4.57 mmol) in acetic acid (22.85 mL) was S added 4-fluoroaniline (4.33 ml, 45.7 mmol). The mixture was heated to 70° C. for 24 h. After cooling to rt the mixture was diluted with water and ether and stirred vigorously, filtered and dried to provide 1.67 g (91%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09006387B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-8facd0a73fe4459ba68272f5b9cce00d |
|---|
| 出典メモ | uspto-grants-2015_04 |
|---|
