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Methyl chloroformate → (s)-2-((Methoxycarbonyl)amino)-2-phenylacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | L-Phenylglycine | HCID 99291 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (s)-2-((Methoxycarbonyl)amino)-2-phenylacetic acid | HCID 14264559 | 51% |
反応手順
To a solution of (S)-2-amino-2-phenylacetic acid (0.5 g, 3.31 mmol) in dioxane at 0° C. was added NaOH (5.46 g, 10.92 mmol) followed by dropwise addition of methyl chloroformate (0.51 mL, 6.62 mmol) and the solution was warmed to room temperature with stirring over 1 h. Diluted with EtOAc, washed with 1 N HCl, brine, dried (Na2SO4), filtered and removed solvent in vacuo to give the title compound (0.35 g, 1.673 mmol, 51%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09006387B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-128ae61b2efe4ac882cad25c598a9e2c |
| 出典メモ | uspto-grants-2015_04 |