Methanol → HCID 178446053、化合物
反応式
[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:36].[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33]参加物
5
実験手順
Tiotropium bromide (1.4 g) and L-leucine (0.5 g) were dissolved into methanol (60 ml). Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined above.