Bromine → 2-Bromo-4-fluoro-5-methoxybenzaldehyde
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[O:10][CH3:11].[Br-:12].[K+].BrBr>O>[Br:12][C:8]1[CH:9]=[C:2]([F:1])[C:3]([O:10][CH3:11])=[CH:4][C:5]=1[CH:6]=[O:7]参加物
5
実験手順
A solution of 4-fluoro-3-methoxybenzaldehyde (4.3 g, 27.9 mmol), potassium bromide (16.6 g, 139.5 mmol), bromine (3.6 mL, 69.8 mmol), and water (45 mL) were stirred at room temperature for 24 hours. More bromine (1.43 mL, 27.9 mmol) was added and the reaction was stirred at room temperature overnight. The product precipitated out of solution and was collected via filtration and dried under reduced pressure to give 2-bromo-4-fluoro-5-methoxybenzaldehyde (6.01 g, 92% yield).
後処理
- customThe product precipitated out of solution
- filtrationwas collected via filtration
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-8b8869fc1cd0440990fdc2b74201a5e5
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09012431B2
反応ノート
読み込み中…