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HRID 1471840作成日：2026年10月26日

(2-Methyl-1H-indol-5-yl)boronic acid → 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2-methyl-1H-indol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide

https://huagongshe.com/reaction/1471840

反応式

関与物質

役割名称HCID仕込み量
反応物(2-Methyl-1H-indol-5-yl)boronic acidHCID 22558958—
反応物N-(1-Bromoisoquinolin-3-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamideHCID 57732996—
反応物2,2-difluorobenzo[d][1,3]dioxol-5-yl-N-(1-phenylisoquinolin-3-yl)cyclopropanecarboxamideHCID 57733001—
生成物1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2-methyl-1H-indol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamideHCID 57733025—

反応手順

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl-N-(1-phenylisoquinolin-3-yl)cyclopropanecarboxamide was made by the procedure shown above starting from N-(1-bromoisoquinolin-3-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide and 2-methyl-1H-indol-5-ylboronic acid.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09012473B2
出典データセットuspto-grants-2015_04
ORD IDord-3db1073ea1fb4938aceea132f5125a65
出典メモuspto-grants-2015_04