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Triethylamine → N-[4-(dimethylphosphoryl)phenyl]-N'-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-1,3,5-triazine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Hexahydrocyclopenta(c)pyrrol-2(1H)-amine monohydrochloride | HCID 16213802 | — |
| 反応物 | 4-chloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine | HCID 86668817 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-[4-(dimethylphosphoryl)phenyl]-N'-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-1,3,5-triazine-2,4-diamine | HCID 68156874 | — |
反応手順
To a solution of 4-chloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine (prepared as in Example 92: 0.12 mmol) in 2 mL of ethanol is added 50 μL of triethylamine and 3-Amino-3-azabicyclo-[3,3,0]octane hydrochloride salt (19 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture is filtered through a syringe filter and purified by prep-HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09012462B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-24051f35e66b4af2afc59bc50d00ef37 |
| 出典メモ | uspto-grants-2015_04 |