Urea → 6-METHOXYQUINAZOLINE-2,4-DIOL

HRID 1472718ノート

反応式

HRID 1472718 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:6]

参加物

4

反応物 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

生成物 1

HCID 103302006-METHOXYQUINAZOLINE-2,4-DIOL収率 88.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

A mixture of 2-amino-5-methoxybenzoic acid (5.00 g, 29.9 mmol) and urea (5.40 g, 90.0 mmol) was heated to 200° C. for 1 hour. The mixture was cooled to room temperature and diluted with H2O (50 mL), the mixture was filtered off and the precipitate was washed with H2O (10 mL), dried in vacuo to give the product (5.10 g, yield 88%).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe mixture was filtered off
  3. washthe precipitate was washed with H2O (10 mL)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-0e2959cd25884f7cb48f6ce16e6d964d
出典データセット
uspto-grants-2015_04
特許番号
US09012646B2

反応ノート

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