Potassium Carbonate → HCID 67362893、化合物
反応式
C(O[C@@H:5]1[C@H:11]2[C@H:12]3[C@H:21]([CH2:22][CH2:23][C@:8]2([CH2:9][CH3:10])[C:7](=[O:26])[CH2:6]1)[C@@H:20]1[C:15]([CH:16]=[C:17]([O:24][CH3:25])[CH2:18][CH2:19]1)=[CH:14][CH2:13]3)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:25][O:24][C:17]1[CH2:18][CH2:19][C@H:20]2[C:15](=[CH:14][CH2:13][C@@H:12]3[C@@H:21]2[CH2:22][CH2:23][C@@:8]2([CH2:9][CH3:10])[C@H:11]3[CH:5]=[CH:6][C:7]2=[O:26])[CH:16]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 15α-acetoxy-3-methoxy-18-methyl-estra-3,5-dien-17-one (1 g, 2.8 mmol) in suspension in a 1/1 MeOH/water solution (20 ml), and potassium carbonate (1 g, 7.23 mmol) was heated at 50° C. for 1 h. The mixture was allowed to cool to room temperature and the precipitate was filtered, washed with water and dried under vacuum to afford 3-methoxy-18-methyl-estra-3,5,15-trien-17-one (0.67 g, yield: 80%). mp: 159-161° C.; 1H-NMR δ=0.72 (t, 3H), 0.9-2.4 (m, 16H), 3.55 (s, 3H), 5.18 (s, 1H), 5.28 (d, 1H), 5.95 (m, 1H), 7.45 (d, 1H).