Water → 7-Bromo-4-(4-(difluoromethyl)-5-fluoro-2-methoxyphenyl)-2-methylquinazoline

反応式

[F:1][CH:2]([F:21])[C:3]1[C:8]([F:9])=[CH:7][C:6](B2OC(C)(C)C(C)(C)O2)=[C:5]([O:19][CH3:20])[CH:4]=1.[Br:22][C:23]1[CH:32]=[C:31]2[C:26]([C:27](Cl)=[N:28][C:29]([CH3:33])=[N:30]2)=[CH:25][CH:24]=1.C(=O)([O-])[O-].[K+].[K+].O>O1CCOCC1.C(Cl)Cl.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[Br:22][C:23]1[CH:32]=[C:31]2[C:26]([C:27]([C:6]3[CH:7]=[C:8]([F:9])[C:3]([CH:2]([F:1])[F:21])=[CH:4][C:5]=3[O:19][CH3:20])=[N:28][C:29]([CH3:33])=[N:30]2)=[CH:25][CH:24]=1