Water → Perfluorophenyl 4-(2-chloro-3'-fluoro-5-methoxy-[1,1'-biphenyl]-4-yl)quinazoline-7-sulfonate

HRID 1473684ノート

反応式

HRID 1473684 の反応式
C([S:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:19]3[C:24]([O:25][CH3:26])=[CH:23][C:22]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=4)=[C:21]([Cl:34])[CH:20]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.ClN1C(C)(C)C(=[O:43])N(Cl)C1=O.[F:46][C:47]1[C:52]([F:53])=[C:51]([F:54])[C:50]([F:55])=[C:49]([F:56])[C:48]=1[OH:57].C(N(CC)CC)C.[OH2:65]>C(O)(=O)C.C(Cl)Cl>[Cl:34][C:21]1[CH:20]=[C:19]([C:13]2[C:12]3[C:17](=[CH:18][C:9]([S:8]([O:57][C:48]4[C:47]([F:46])=[C:52]([F:53])[C:51]([F:54])=[C:50]([F:55])[C:49]=4[F:56])(=[O:43])=[O:65])=[CH:10][CH:11]=3)[N:16]=[CH:15][N:14]=2)[C:24]([O:25][CH3:26])=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=1

参加物

8

反応物 5

HCID 962WaterHCID 83601,3-Dichloro-5,5-dimethylhydantoinHCID 8471TriethylamineHCID 13041PentafluorophenolHCID 866877667-(Benzylthio)-4-(2-chloro-3'-fluoro-5-methoxy-[1,1'-biphenyl]-4-yl)quinazoline

生成物 1

HCID 86687767Perfluorophenyl 4-(2-chloro-3'-fluoro-5-methoxy-[1,1'-biphenyl]-4-yl)quinazoline-7-sulfonate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

A round-bottom flask was charged with 7-(benzylthio)-4-(2-chloro-3′-fluoro-5-methoxy-[1,1′-biphenyl]-4-yl)quinazoline (0.490 g, 1.006 mmol), DCM (9.47 ml), DCM (9.47 ml), Acetic Acid (0.355 ml), and Water (0.237 ml) to give a thin suspension. The flask was cooled in an ice-bath for 10 min, then 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (0.496 g, 2.52 mmol) was added in one portion, leading to a solution. The reaction was stirred for 15 minutes. 2,3,4,5,6-pentafluorophenol (0.211 ml, 2.012 mmol) was added followed by drop wise addition of triethylamine (0.351 ml, 2.52 mmol). The reaction was stirred for 30 minutes. The reaction was concentrated and purified via column chromatography (RediSep Gold 40 g, gradient elution 0-50% EtOAc:Heptane) to afford perfluorophenyl 4-(2-chloro-3′-fluoro-5-methoxy-[1,1′-biphenyl]-4-yl)quinazoline-7-sulfonate as a light yellow solid. (ESI) 611.2 (M+H)+.

後処理

  1. customto give a thin suspension
  2. temperatureThe flask was cooled in an ice-bath for 10 min
  3. stirringThe reaction was stirred for 30 minutes
  4. concentrationThe reaction was concentrated
  5. custompurified via column chromatography (RediSep Gold 40 g, gradient elution 0-50% EtOAc:Heptane)

出典と根拠

ORDレコード
ord-bca14eeb282c4bcd81edc7fe47d9559d
出典データセット
uspto-grants-2015_04
特許番号
US09012443B2

反応ノート

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