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2-(3-Fluorophenyl)ethanamine → [2-(3-Fluoro-phenyl)-ethyl]-{4-[3-(piperidin-4-ylamino)-phenyl]-pyrimidin-2-yl}-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(3-Fluorophenyl)ethanamine | HCID 533928 | — |
| 反応物 | 4-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603244 | — |
| 生成物 | [2-(3-Fluoro-phenyl)-ethyl]-{4-[3-(piperidin-4-ylamino)-phenyl]-pyrimidin-2-yl}-amine | HCID 58603618 | — |
反応手順
Intermediate 7 was coupled with 2-(3-fluoro-phenyl)-ethylamine following procedure F and the resulting product deprotected following procedure G. LC-MS showed the product had the expected M+H+ of 393. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.2 (d, 1H) 6.95-7.6 (m, 8H) 6.9 (m, 1H) 4.95 (m, 1H) 3.6-4.0 (m, 3H) 3.4 (m, 3H) 3.15 (m, 2H) 3.0 (m, 2H) 2.25 (m, 2H) 1.7 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-39ee7e4352a64cb39dbf4cf2e2cf2f97 |
| 出典メモ | uspto-grants-2010_06 |