関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Bromothiazole | HCID 76430 | — |
| 反応物 | 3-Amino-5-methylphenol | HCID 3018667 | — |
| 生成物 | 2-Methyl-5-(thiazol-2-ylamino)phenol | HCID 86645029 | 74% |
反応手順
Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.27 mL, 3.05 mmol), 5-amino-3-methylphenol (188 mg, 1.5 mmol) and 37% HCl solution (0.26 mL, 3.05 mmol) in 10% aqueous EtOH solution (5 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 74% yield (233 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09018209B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
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| ORD ID | ord-349dc3502ff949eb9b00a037f64d2998 |
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| 出典メモ | uspto-grants-2015_04 |
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