Hydrochloric Acid → 2-Ethyl-5-(thiazol-2-ylamino)phenol
反応式
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH2:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:15][CH3:16])=[C:12]([OH:14])[CH:13]=1.Cl>CCO>[CH2:15]([C:11]1[CH:10]=[CH:9][C:8]([NH:7][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[CH:13][C:12]=1[OH:14])[CH3:16]参加物
5
反応条件
- 温度
- 90 °C
実験手順
Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.35 mL, 3.86 mmol), 5-amino-2-ethylphenol (265 mg, 1.93 mmol) and 37% HCl solution (0.32 mL, 3.86 mmol) in 10% aqueous EtOH solution (10 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 6/4) in 69% yield (292 mg).
出典と根拠
- ORDレコード
- ord-69ccefde9d4142ad8000883abe6dfb9b
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09018209B2
反応ノート
読み込み中…