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m-Tyramine → 3-(2-{4-[3-(Piperidin-4-ylamino)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Tyramine | HCID 11492 | — |
| 反応物 | 4-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603244 | — |
| 生成物 | 3-(2-{4-[3-(Piperidin-4-ylamino)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol | HCID 58603375 | — |
反応手順
Intermediate 7 was coupled with 3-(2-amino-ethyl)-phenol following procedure F and the resulting product deprotected following procedure G. LC-MS showed the product had the expected M+H+ of 390. 1H NMR (Varian 300 MHz, DMSO-d6, shifts relative to the solvent peak at 2.49 ppm) δ 8.8 (m, 5H) 8.4 (d, 1H) 7.4 (m, 2H) 7.3 (m, 1H) 7.0 (d, 1H) 6.9 (m, 1H) 3.7 (m, 2H) 3.4 (m, 1H) 3.1 (m, 2H) 2.9 (m, 3H) 2.1 (m, 1H) 1.8 (m, 2H) 1.5 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-1c41f251b0234618ac93c514768b520e |
| 出典メモ | uspto-grants-2010_06 |