関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Chloropyrimidine | HCID 74404 | — |
| 反応物 | 4-Amino-2-hydroxybenzonitrile | HCID 12468682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Cyano-5-(pyrimidin-2-ylamino)phenol | HCID 68487685 | 5% |
反応手順
Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-chloropyrimidine (209 mg, 1.8 mmol) and 4-amino-2-hydroxybenzonitrile (123 mg, 0.9 mmol) in 10% aqueous EtOH (5 mL) was heated at 90° C. for 18 h. The title compound was obtained in 5% yield a (10 mg) and used for the next step without additional purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09018209B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-a44e6973722c440b835bdf323bdcfb92 |
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| 出典メモ | uspto-grants-2015_04 |
|---|
