化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → Taxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Menthol | HCID 1254 | — |
| 反応物 | Paclitaxel | HCID 36314 | — |
| 反応物 | Docetaxel | HCID 148124 | — |
| 反応物 | Larotaxel | HCID 6918260 | — |
| 反応物 | Cabazitaxel | HCID 9854073 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Glycerol | HCID 753 | — |
| 生成物 | Taxane | HCID 9548828 | — |
反応手順
200 mg of an active drug (docetaxel, paclitaxel, cabazitaxel, or larotaxel) is weighed into a 5 mL volumetric flask. 2 g polysorbate 80 is added to the flask and votexed for 3 minutes. Then glycerol (0.5 g), polyvinylpyrrolidone (0.5 g), citric acid (0.05 g), menthol (0.025 g) are added to the flask. Ethanol is then added to make the total volume of 5 mL. The solution is votexed for 5 minutes and mixed well. The final pH is 5.3 (range 5.0-6.0).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09018246B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-5318a8c403df42548fa8f6d6c31fc5b4 |
| 出典メモ | uspto-grants-2015_04 |