Tert-butyl 3-oxopyrrolidine-1-carboxylate → 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 14745

反応式

HRID 14745 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:14])[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][C:24](=O)[CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][CH:24]([NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:23]1)=[O:21])([CH3:18])([CH3:16])[CH3:17]

参加物

3

反応物 2

HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 593410233-(2-Chloropyrimidin-4-yl)aniline

生成物 1

HCID 866032463-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester収率 70%

実験手順

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

後処理

  1. customThe product was purified on silica gel using 1:1 ethyl acetate

出典と根拠

ORDレコード
ord-1fc235b6f85a43b4a99287ff419e95a2
出典データセット
uspto-grants-2010_06
特許番号
US07732444B2

関連ノート

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