Ethanol → 5-Methyl-2,3-dihydro-1-benzofuran-7-amine

HRID 1474525ノート

反応式

HRID 1474525 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.C(O)C>ClCCl.[C].[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

参加物

5

反応物 2

HCID 702EthanolHCID 552848275-Methylbenzofuran-7-amine

生成物 1

HCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amine収率 87.6%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

後処理

  1. customfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
  2. customThe catalyst was removed by celite filtration
  3. customcondensed under reduced pressure
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-f53b8641045c4f2dbd2b849205adb762
出典データセット
uspto-grants-2015_04
特許番号
US09018229B2

反応ノート

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