4,7-Difluoro-2,3-dihydro-1H-inden-1-amine → HCID 117736897、化合物

HRID 1474576ノート

反応式

HRID 1474576 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH2:12].[C:13]([O:17][C:18]([N-:20][S:21](N1C=CC(=[N+](C)C)C=C1)(=[O:23])=[O:22])=[O:19])([CH3:16])([CH3:15])[CH3:14]>C(Cl)Cl.CCOC(C)=O.Cl>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:12][S:21]([NH:20][C:18](=[O:19])[O:17][C:13]([CH3:15])([CH3:14])[CH3:16])(=[O:22])=[O:23]

参加物

6

反応物 2

HCID 584399044,7-Difluoro-2,3-dihydro-1H-inden-1-amineHCID 178482962HCID 178482962、化合物

生成物 1

HCID 117736897HCID 117736897、化合物

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4,7-difluoro-2,3-dihydro-1H-inden-1-amine (CAS No. 625471-13-8, 1.19 g, 11.2 mmol) in DCM (50 mL) were added [(tert-Butoxy)carbonyl]{[4-(dimethyliminio)pyridin-1(4H)-yl]sulfonyl}amide (3.70 g, 12.3 mmol) and TEA (4.66 mL, 33.5 mmol) at room temperature. The resulting solution was stirred for 75 hours at room temperature. The reaction mixture was diluted with AcOEt and 1N HCl and the layers were separated. The organic layer was dried over anhydrous Na2SO4 and evaporated in vacuo to afford the title compound (3.82 g, 11.0 mmol).

後処理

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over anhydrous Na2SO4
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-9d3a9702ac064e4abd005287323ba8e3
出典データセット
uspto-grants-2015_04
特許番号
US09018260B2

反応ノート

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