Hydrochloric Acid → 6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-1H-indole

HRID 1475322ノート

反応式

HRID 1475322 の反応式
[CH2:1]([S:3]([C:6]1[CH:14]=[C:13]2[C:9]([C:10]([CH3:19])([CH3:18])[CH2:11][N:12]2C(=O)C)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].Cl>CO>[CH2:1]([S:3]([C:6]1[CH:14]=[C:13]2[C:9]([C:10]([CH3:18])([CH3:19])[CH2:11][NH:12]2)=[CH:8][CH:7]=1)(=[O:4])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 709808661-(6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone

生成物 1

HCID 867239446-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-1H-indole収率 54.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
90 °C

実験手順

1-(6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone (130 mg, 0.46 mmol) was dissolved in MeOH (7 mL) and 5 M hydrochloric acid (920 μL, 4.6 mmol) was added. The solution was stirred at 90° C. for 1.5 h then solvent was removed in vacuo. The residue was quenched with saturated aqueous NaHCO3 and the product extracted with EtOAc. The organic phase was dried (MgSO4), filtered and concentrated to give the title compound (60 mg), used without further purification. MS: [M+H]+=240.

後処理

  1. customsolvent was removed in vacuo
  2. customThe residue was quenched with saturated aqueous NaHCO3
  3. extractionthe product extracted with EtOAc
  4. dry with materialThe organic phase was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-bcc0d8f9ef264edf84cee1e2bd8622bf
出典データセット
uspto-grants-2015_04
特許番号
US09018214B2

反応ノート

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